{"id":138,"date":"2018-01-28T09:54:03","date_gmt":"2018-01-28T00:54:03","guid":{"rendered":"https:\/\/metaboliz.net\/insulin\/?p=138"},"modified":"2024-10-25T15:42:06","modified_gmt":"2024-10-25T06:42:06","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%af%e8%82%a5%e6%ba%80%e4%bd%93%e8%b3%aa%e3%81%ae%e4%ba%ba%e3%81%ae%e7%97%85%e6%b0%97%e3%81%8b%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/metaboliz.net\/insulin\/archives\/138","title":{"rendered":"\u7cd6\u5c3f\u75c5 \u3084\u305b \u3067\u3082\u306a\u308b"},"content":{"rendered":"<p>\u7cd6\u5c3f\u75c5 \u3084\u305b 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25\u672a\u6e80\u306a\u3089\u300c\u6a19\u6e96\u4f53\u91cd\u300d\u3001\u305d\u308c\u4ee5\u4e0b\u306a\u3089\u300c\u3084\u305b\uff08\u4f4e\u4f53\u91cd\uff09\u300d\u3001\u305d\u308c\u4ee5\u4e0a\u3060\u3063\u305f\u3089\u300c\u80a5\u6e80\u300d\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u80a5\u6e80\u5ea6\u6307\u6570\u3067\u898b\u305f\u65e5\u672c\u4eba\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u4e2d\u5fc3\u306f\u300122.5\uff5e23.0\u3002\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u5c11\u3057\u3082\u592a\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u3080\u3057\u308d\u3001\u307b\u307c\u6a19\u6e96\u4f53\u91cd\u3067\u3059\u3002<\/p>\n<p>\u7cd6\u5c3f\u75c5\u306f\u592a\u3063\u3066\u3044\u308b\u4eba\u306e\u75c5\u6c17\u304b\u3002\u3053\u306e\u7b54\u3048\u306f\u3001\u300c\u30ce\u30fc\u300d\u3067\u3059\u3002\u65e5\u672c\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e7\uff5e8\u5272\u306f\u592a\u3063\u3066\u3044\u306a\u3044\u4eba\u306a\u306e\u3067\u3059\u3002\u307f\u306a\u3055\u3093\u3082\u304a\u77e5\u308a\u5408\u3044\u306e\u7cd6\u5c3f\u75c5\u306e\u4eba\u3092\u601d\u3044\u6d6e\u304b\u3079\u3066\u304f\u3060\u3055\u3044\u3002\u305d\u306e\u4eba\u306f\u592a\u3063\u3066\u3044\u307e\u3059\u304b\uff1f \u3082\u3057\u592a\u3063\u3066\u3044\u308b\u306a\u3089\u300140\uff5e60\u6b73\u307e\u3067\u306e\u3001\u6bd4\u8f03\u7684\u82e5\u3044\u4eba\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>70\u6b73\u3092\u8d85\u3048\u305f\u4eba\u3067\u592a\u3063\u3066\u3044\u308b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306f\u3001\u3080\u3057\u308d\u5c11\u306a\u3044\u3068\u3044\u3046\u306e\u304c\u79c1\u306e\u7387\u76f4\u306a\u611f\u60f3\u3067\u3059\u3002\u592a\u3063\u3066\u3044\u308b\u304b\u3089\u7cd6\u5c3f\u75c5\u306b\u306a\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002\u3080\u3057\u308d\u3001\u65e5\u672c\u4eba\u306f\u3084\u305b\u305f\u307e\u307e\u7cd6\u5c3f\u75c5\u306b\u306a\u308b\u3002\u305d\u3046\u3044\u3046\u904b\u547d\u3092\u80cc\u8ca0\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<h3>\u7cd6\u5c3f\u75c5 \u80a5\u6e80 \u3067\u306a\u304f\u3066\u3082\u306a\u308b\u7406\u7531<\/h3>\n<p>\u7cd6\u5c3f\u75c5\u304c\u80a5\u6e80\u3067\u306a\u304f\u3066\u3082\u767a\u75c7\u3059\u308b\u7406\u7531\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u554f\u984c\u3084\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3001\u5185\u81d3\u8102\u80aa\u3001\u751f\u6d3b\u7fd2\u6163\u3001\u74b0\u5883\u8981\u56e0\u306a\u3069\u306e\u8907\u96d1\u306a\u8981\u7d20\u304c\u7d61\u3093\u3067\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u30a2\u30b8\u30a2\u4eba\u3067\u306f\u3084\u305b\u578b\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u304c\u591a\u304f\u3001\u6b27\u7c73\u4eba\u3068\u306f\u7570\u306a\u308b\u75c5\u614b\u304c\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n<h3>\u7cd6\u5c3f\u75c5\u304c\u80a5\u6e80\u3067\u306a\u304f\u3066\u3082\u767a\u75c7\u3059\u308b\u7406\u7531<\/h3>\n<h4>1. <strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u554f\u984c<\/strong><\/h4>\n<p><strong>\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306e\u4e0d\u5168<\/strong><\/p>\n<ul>\n<li><strong>\u30a2\u30b8\u30a2\u4eba<\/strong>\u3092\u542b\u3080\u4e00\u90e8\u306e\u4eba\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u80fd\u529b\u304c\u4f4e\u3044\u3053\u3068\u304c\u591a\u304f\u3001\u3053\u308c\u304c\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u5bc4\u4e0e\u3057\u307e\u3059 \u3002<\/li>\n<li><strong>\u03b2\u7d30\u80de\u6a5f\u80fd\u306e\u4f4e\u4e0b<\/strong>: \u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5206\u6ccc\u3059\u308b\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u304c\u5341\u5206\u3067\u306a\u304f\u306a\u308a\u3001\u7cd6\u5c3f\u75c5\u304c\u767a\u75c7\u3057\u307e\u3059 \u3002<\/li>\n<\/ul>\n<h4>2. <strong>\u907a\u4f1d\u7684\u8981\u56e0<\/strong><\/h4>\n<p><strong>\u7cd6\u5c3f\u75c5\u95a2\u9023\u907a\u4f1d\u5b50<\/strong><\/p>\n<ul>\n<li><strong>TCF7L2<\/strong>\u3001<strong>KCNQ1<\/strong>\u3001<strong>CDKAL1<\/strong>\u306a\u3069\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3084\u4f5c\u7528\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059 \u3002<\/li>\n<li><strong>\u5bb6\u65cf\u6b74<\/strong>: \u7cd6\u5c3f\u75c5\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u5834\u5408\u3001\u907a\u4f1d\u7684\u306a\u5f71\u97ff\u3067\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059 \u3002<\/li>\n<\/ul>\n<h4>3. <strong>\u5185\u81d3\u8102\u80aa<\/strong><\/h4>\n<p><strong>\u5185\u81d3\u8102\u80aa\u306e\u84c4\u7a4d<\/strong><\/p>\n<ul>\n<li>\u3084\u305b\u3066\u3044\u3066\u3082\u5185\u81d3\u8102\u80aa\u304c\u591a\u3044\u5834\u5408\u3001\u305d\u306e\u8102\u80aa\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u8102\u80aa\u9178\u3084\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u8840\u7cd6\u5024\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u60aa\u5316\u3055\u305b\u307e\u3059 \u3002<\/li>\n<li><strong>\u8102\u80aa\u809d<\/strong>: \u5185\u81d3\u8102\u80aa\u304c\u591a\u3044\u3068\u8102\u80aa\u809d\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u3053\u308c\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u5f37\u3081\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059 \u3002<\/li>\n<\/ul>\n<h4>4. <strong>\u751f\u6d3b\u7fd2\u6163\u3068\u74b0\u5883\u8981\u56e0<\/strong><\/h4>\n<p><strong>\u98df\u751f\u6d3b<\/strong><\/p>\n<ul>\n<li><strong>\u9ad8\u7cd6\u8cea\u306e\u98df\u4e8b<\/strong>: \u4e3b\u98df\u3084\u9593\u98df\u306b\u9ad8\u7cd6\u8cea\u306e\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3068\u3001\u98df\u5f8c\u9ad8\u8840\u7cd6\u304c\u6162\u6027\u7684\u306b\u7d9a\u304d\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3057\u307e\u3059 \u3002<\/li>\n<li><strong>\u6804\u990a\u30d0\u30e9\u30f3\u30b9\u306e\u4e71\u308c<\/strong>: \u6804\u990a\u306e\u504f\u308a\u304c\u3042\u308b\u98df\u4e8b\u306f\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002<\/li>\n<\/ul>\n<p><strong>\u904b\u52d5\u4e0d\u8db3<\/strong><\/p>\n<ul>\n<li><strong>\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u306e\u4e0d\u8db3<\/strong>: \u65e5\u5e38\u751f\u6d3b\u3067\u904b\u52d5\u304c\u4e0d\u8db3\u3059\u308b\u3068\u3001\u98df\u4e8b\u3067\u6442\u53d6\u3057\u305f\u7cd6\u8cea\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u6d88\u8cbb\u3055\u308c\u305a\u3001\u8840\u7cd6\u5024\u304c\u4e0a\u6607\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059 \u3002<\/li>\n<\/ul>\n<p><strong>\u30b9\u30c8\u30ec\u30b9\u3068\u7761\u7720\u4e0d\u8db3<\/strong><\/p>\n<ul>\n<li><strong>\u30b9\u30c8\u30ec\u30b9<\/strong>: \u9577\u671f\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306f\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3092\u4e71\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059 \u3002<\/li>\n<li><strong>\u7761\u7720\u4e0d\u8db3<\/strong>: \u7761\u7720\u4e0d\u8db3\u306f\u8840\u7cd6\u8abf\u7bc0\u306b\u95a2\u308f\u308b\u30db\u30eb\u30e2\u30f3\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3057\u3001\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u307e\u3059 \u3002<\/li>\n<\/ul>\n<h4>5. <strong>\u305d\u306e\u4ed6\u306e\u8981\u56e0<\/strong><\/h4>\n<p><strong>\u52a0\u9f62<\/strong><\/p>\n<ul>\n<li>\u5e74\u9f62\u3092\u91cd\u306d\u308b\u3068\u3001\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u306a\u308a\u3001\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059 \u3002<\/li>\n<\/ul>\n<p><strong>\u5468\u7523\u671f\u306e\u5f71\u97ff<\/strong><\/p>\n<ul>\n<li><strong>\u80ce\u5150\u671f\u306e\u6804\u990a\u4e0d\u8db3<\/strong>: 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20\u3001\u30b9\u30c8\u30ec\u30b9\u304c\u591a\u3044\u8077\u696d\u3067\u3001\u7cd6\u8cea\u304c\u591a\u3044\u98df\u751f\u6d3b\u3002\u8840\u7cd6\u5024\u306e\u5909\u52d5\u304c\u5927\u304d\u304f\u3001\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3002<\/li>\n<\/ul>\n<h4><strong>\u6cbb\u7642\u6cd5<\/strong><\/h4>\n<ul>\n<li><strong>\u98df\u4e8b\u7642\u6cd5<\/strong>: \u4f4eGI\u98df\u54c1\u3084\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u3092\u63a8\u5968\u3002<\/li>\n<li><strong>\u904b\u52d5\u7642\u6cd5<\/strong>: \u5b9a\u671f\u7684\u306a\u6709\u9178\u7d20\u904b\u52d5\u3084\u7b4b\u30c8\u30ec\u3092\u5b9f\u65bd\u3002<\/li>\n<li><strong>\u85ac\u7269\u7642\u6cd5<\/strong>: \u5fc5\u8981\u306b\u5fdc\u3058\u3066\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4fc3\u9032\u5264\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u85ac\u3092\u4f7f\u7528\u3002<\/li>\n<li><strong>\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406<\/strong>: \u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3084\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u6cd5\u306e\u5c0e\u5165\u3002<\/li>\n<\/ul>\n<h3>\u7d50\u8ad6<\/h3>\n<p>\u7cd6\u5c3f\u75c5\u306f\u80a5\u6e80\u3067\u306a\u304f\u3066\u3082\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4e3b\u306a\u539f\u56e0\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u4e0d\u5168\u3084\u907a\u4f1d\u7684\u8981\u56e0\u3001\u5185\u81d3\u8102\u80aa\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u554f\u984c\u306a\u3069\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u3044\u307e\u3059\u3002\u7cd6\u5c3f\u75c5\u4e88\u9632\u3068\u7ba1\u7406\u306b\u306f\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u53d6\u308c\u305f\u98df\u4e8b\u3001\u5b9a\u671f\u7684\u306a\u904b\u52d5\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p><a 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